Effectiveness of Personalized Hippocampal Network–Targeted Stimulation in Alzheimer DiseaseA Randomized Clinical Trial

Key Points

Question  Can 4-week personalized hippocampal network–targeted stimulation improve cognition in Alzheimer disease?

Findings  In this randomized clinical trial including 30 participants, personalized hippocampal network–targeted stimulation demonstrated a significant improvement in cognition and functional performances compared with the sham group at 8 weeks, with significant improvements evident at 4 weeks after the end of stimulation. Stimulation also increased functional connectivity between the hippocampus and precuneus, with changes correlated with improvements in cognition.

Meaning  These results suggest that personalized hippocampal networ–targeted stimulation could be considered as a viable nonpharmacological treatment of Alzheimer disease.